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Introducing uplift

Adaptogens are a class of herbs and mushrooms that are believed to help the body resist stressors of various kinds, whether physical, chemical, or biological. They're thought to work by supporting the body's ability to adapt to stress and maintain balance, or homeostasis, within the body. These natural substances have been used for centuries in traditional medicine systems such as Ayurveda and Traditional Chinese Medicine.

• Supports healthy cortisol levels*
  
• Helps reduce oxidative stress*
  
• Supports reduction of occasional stress*
  
• Supports antioxidant capacity*
  
• Supports healthy glutathione levels*
  
• Supports immune function*
  
• Supports cognitive function*
  
• Supports skin health*
  
• Optimizes energy*
  

Let’s break down the ingredients...

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Ashwagandha, also known as Withania somnifera, is an adaptogenic herb that has been used in traditional Ayurvedic medicine for centuries.

Schisandra, also known as Schisandra chinensis, is a berry-bearing vine native to East Asia and Russia. It has a long history of use in traditional Chinese medicine.

American ginseng (Panax quinquefolius) is a herb native to North America and has been used for centuries in traditional medicine.

Sicilian blood oranges, also known as "sanguinello" or "tarocco" oranges, are a unique variety of oranges native to Sicily, Italy. They are prized for their distinctive crimson flesh, which is due to the presence of anthocyanins, a type of antioxidant pigment not commonly found in citrus fruits.

*The Uplift supplement contains three varieties of this these, difficult to find, powerhouse fruits

Acerola, also known as Barbados cherry or West Indian cherry, is a tropical fruit native to the Caribbean, Central America, and northern South America. It is renowned for its exceptionally high vitamin C content, making it one of the richest natural sources of this essential nutrient.

Rutin, also known as rutoside or vitamin P, is a bioflavonoid found in certain fruits, vegetables, and plant-based foods. It is known for its antioxidant and anti-inflammatory properties and is often used as a dietary supplement.

A group of polyphenolic compounds found in citrus fruits such as oranges, lemons, grapefruits, and limes. They are known for their antioxidant and anti-inflammatory properties, and they offer several potential health benefits.

The Power of Glutathione

Glutathione is a tripeptide molecule composed of three amino acids: glutamine, cysteine, and glycine. It is a powerful antioxidant found in virtually every cell of the body, where it plays a crucial role in neutralizing free radicals and reactive oxygen species (ROS) that can damage cells and contribute to aging, disease, and oxidative stress.

Glutathione is a tripeptide molecule composed of three amino acids: glutamine, cysteine, and glycine. It is a powerful antioxidant found in virtually every cell of the body, where it plays a crucial role in neutralizing free radicals and reactive oxygen species (ROS) that can damage cells and contribute to aging, disease, and oxidative stress.

Glutathione exists in two forms: reduced glutathione (GSH) and oxidized glutathione (GSSG). The majority of glutathione in cells is in its reduced form (GSH), which is the active form responsible for antioxidant activity. When GSH neutralizes free radicals, it becomes oxidized (GSSG). However, enzymes within the body can recycle GSSG back into GSH, maintaining a balance of glutathione levels.

Aside from its role as an antioxidant, glutathione is involved in several other important functions in the body:

Glutathione levels can be influenced by various factors, including age, diet, lifestyle, and environmental exposures. Low levels of glutathione have been associated with various health conditions, including aging, chronic diseases, and impaired immune function.

Supplementation with glutathione precursors, such as N-acetylcysteine (NAC) and alpha-lipoic acid, or with glutathione itself, has been explored as a potential therapeutic strategy for boosting glutathione levels and supporting health. However, the effectiveness of oral glutathione supplementation is still debated due to issues with absorption and bioavailability. Intravenous administration of glutathione may be more effective for increasing systemic levels in some cases.

Overall, glutathione is a crucial molecule with diverse functions in the body, and maintaining adequate levels of glutathione is important for overall health and well-being.

Uplift works to support healthy glutathione levels

Published Studies

Helping you make healthier choices

& live your best life

Most Seratonin is produced in the gut.

Research has been one of the love’s of my life ever since grad school, I take pride in it, I love the information I can find through it, and I enjoy the tedious task of it.

I find it hard to trust information without solid and available research, so I have compiled these sources for both the avid researcher, as well as those who simply need to see the proof. It’s no surprise that everyone is selling something online. I choose only to share products I understand and believe in, for the sake of my customers and future customers, who I care for and am so deeply appreciative of.

More so, I know that it’s definitely not everyone’s love language is deep diving into medical journals, but understanding the benefits of a product will help anyone to desire to build the habit of regularly incorporating it into their life and daily routine. I hope that this information has given you insight and I’m always happy to help answer any questions.

Links to Research: Schisandra

1. Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia\
   
2. The influence of Schisandrin B on a model of Alzheimer's disease using β-amyloid protein Aβ1-42-mediated damage in SH-SY5Y neuronal cell line and underlying mechanisms
   
3. Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice
4. A randomized, double-blind, placebo-controlled trial of Schisandra chinensis for menopausal symptoms
5. The effect of Schisandra chinensis extracts on depression by noradrenergic, dopaminergic, GABAergic and glutamatergic systems in the forced swim test in mice
6. Pharmacology of Schisandra chinensis Bail.: An overview of Russian research and uses in medicine
7. The Effects of Stress on Your Body
   

Links to Research: American Ginseng

1. Ginseng: An Nonnegligible Natural Remedy for Healthy Aging
   
2. Antioxidant, Anti-Inflammatory and Antithrombotic Effects of Ginsenoside Compound K Enriched Extract Derived from Ginseng Sprouts
   
3. Ginseng: An Nonnegligible Natural Remedy for Healthy Aging
   
4. Anti-Inflammatory Potential of Cultured Ginseng Roots Extract in Lipopolysaccharide-Stimulated Mouse Macrophages and Adipocytes
   
5. Effects of Panax ginseng and ginsenosides on oxidative stress and cardiovascular diseases: pharmacological and therapeutic roles
   
6. American Ginseng Attenuates Eccentric Exercise-Induced Muscle Damage via the Modulation of Lipid Peroxidation and Inflammatory Adaptation in Males
7. Efficacy and safety of American ginseng (Panax quinquefolius L.) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: a double-blind, randomized, cross-over clinical trial
   
8. Szczuka D, Nowak A, Zakłos-Szyda M, et al. American Ginseng (Panax quinquefolium L.) as a source of bioactive phytochemicals with pro-health properties. Nutrients. 2019;11(5):1041. doi:10.3390/nu11051041
9. American Ginseng.
   
10. Panax ginseng and Panax quinquefolius: From pharmacology to toxicology
11. The safety and efficacy of botanicals with nootropic effects
12. Ginseng as a treatment for fatigue: A systematic review.
13. . Integrative therapies for cancer-related fatigue.
14. Improved working memory performance following administration of a single dose of American ginseng (Panax quinquefolius L.) to healthy middle-age adults
15. A randomized, placebo-controlled trial investigating the acute and chronic benefits of American ginseng (Cereboost®) on mood and cognition in healthy young adults, including in vitro investigation of gut microbiota changes as a possible mechanism of action
16. HT1001, a proprietary North American ginseng extract, improves working memory in schizophrenia: a double-blind, placebo-controlled study.
17. The effect of ginseng (the genus panax) on glycemic control: a systematic review and meta-analysis of randomized controlled clinical trials
18. Efficacy and safety of American ginseng (Panax quinquefolius L.) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: a double-blind, randomized, cross-over clinical trial.
19. Prevention and treatment of influenza, influenza-like illness, and common cold by herbal, complementary, and natural therapies.
20. Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial.
21. Ginseng integrative supplementation for seasonal acute upper respiratory infections: A systematic review and meta-analysis.
22. Supplementation of plants with immunomodulatory properties during pregnancy and lactation-maternal and offspring health effects
    

Links to Research: Acerola

1. Vitamin C and carotenoids in organic and conventional fruits grown in Brazil
2. Cardosoa PC, et al. (2011). Vitamin C andcarotenoids in organic and conventional fruits grown in Brazil. DOI:
3. Manogna C, et al. (2016). Evaluation ofcytotoxic activity of various extracts of sweet cherry (Prunus avium) against human colorectal adenocarcinoma HT-29 cellline.
   
4. Morton J. (1987). Barbados cherry.
5. Rufino M, et al. (2010). Bioactive compounds andantioxidant capacities of 18 non-traditional tropical fruits from Brazil. DOI:
   

Links to Research: Rutin

1. Chua, L. S. (2013, December). A review onplant-based rutin extraction methods and its pharmacological activities[Abstract}. Journal of Ethnopharmacology,150(3), 805-817.
2. Ostrakhovitch, E. a., Afanas’ev, I. B. (2001,September 15). Oxidative stress in rheumatoid arthritis leukocytes: Suppressionby rutin and other antioxidants and chelators. Biochemistry Pharmacology, 62(6), 743-746.
3. Prescott, B. (2012, May 9). Flavonoid compoundcan prevent blood clots. Harvard Gazette.
4. Sattanathan, K., Dhanapal, C. K., &Manavala, R. (2010, December). LDL lowering properties of rutin in diabeticpatients. International Journal of Pharmaand Bio Sciences, 1(4), 467-473.
5. Sumera, W. (n.d.). Rutin
6. A review on plant-based rutin extraction methods and its pharmacological activities
   

Links to Research: Citrus Bioflavinoids

1. Protection of ascorbic acid from copper(II)-catalyzed oxidative degradation in the presence of flavonoids: quercetin, catechin and morin
   
2. Citrus flavonoids and lipid metabolism
3. Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity
4. Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney
5. Flavonoids, Inflammation and Immune System
   
6. The Anti-Aging Potential of Neohesperidin and Its Synergistic Effects with Other Citrus Flavonoids in Extending Chronological Lifespan of Saccharomyces Cerevisiae BY4742
   
7. Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health

Links to Research: Sicilian Blood Oranges

1. Bioactive compounds in blood oranges (Citrus sinensis (L.) Osbeck): Level and intake
2. Cyanidin-3-O-glucoside: Physical-Chemistry, Foodomics and Health Effects
   
3. Changes in Bioactive Compounds, Antioxidant Activity, and Nutritional Quality of Blood Orange Cultivars at Different Storage Temperatures
   
4. Citrus fruits as a treasure trove of active natural metabolites that potentially provide benefits for human health
5. Bioactive compounds in blood oranges (Citrus sinensis (L.) Osbeck): Level and intake
6. Role in Metabolism: https://fdc.nal.usda.gov/fdc-app.html#/food-details/1745219/nutrients
   
7. Changes in Intake of Fruits and Vegetables and Weight Change in United States Men and Women Followed for Up to 24 Years: Analysis from Three Prospective Cohort Studies
   
8. Dietary citrus and/or its extracts intake contributed to weight control: Evidence from a systematic review and meta-analysis of 13 randomized clinical trials
   
9. Immunoregulatory impact of food antioxidants
10. ANTITUMOR EFFECTS OF CHRYSANTHEMIN IN PC-3 HUMAN PROSTATE CANCER CELLS ARE MEDIATED VIA APOPTOSIS INDUCTION, CASPASE SIGNALLING PATHWAY AND LOSS OF MITOCHONDRIAL MEMBRANE POTENTIAL
    
11. Caffeic Acid Versus Caffeic Acid Phenethyl Ester in the Treatment of Breast Cancer MCF-7 Cells: Migration Rate Inhibition
12. Inhibitory effect of caffeic acid on cancer cell proliferation by oxidative mechanism in human HT-1080 fibrosarcoma cell line
    

Links to Research: Quercitin

1. Abharzanjani F, et al. (2017). Short-term high dose of quercetin and resveratrol alters aging markers in human kidney cells.
2. Andres S, et al. (2017). Safety aspects of the use of quercetin as a dietary supplement.
3. Bischoff S C, et al. (2008). Quercetin: potentials in the prevention and therapy of disease
4. Boots A W, et al. (2008). Health effects of quercetin: from antioxidant to nutraceutical.
5. Bule M, et al. (2019). Antidiabetic effect of quercetin: A systematic review and meta-analysis of animal studies.
6. Chassy A W, et al. (2006). Three-year comparison of the content of antioxidant microconstituents and several quality characteristics in organic and conventionally managed tomatoes and bell peppers
7. Chen C K, et al. (1996). Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta.
8. Chirumbolo S. (2011). Quercetin as a potential anti-allergic drug: which perspectives?
9. Chuang C-C, et al. (2010). Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-{alpha}-mediated inflammation and insulin resistance in primary human adipocytes.
10. Costa L G, et al. (2016). Mechanisms of neuroprotection by quercetin: Counteracting oxidative stress and more.
11. D'Andrea G. (2015). Quercetin: A flavonol with multifaceted therapeutic applications?
12. Deng X-H, et al. (2013). Effects of quercetin on the proliferation of breast cancer cells and expression of survivin in vitro.
13. Graefe E U, et al. (2001). Pharmacokinetics and bioavailability of quercetin glycosides in humans.
14. Hashemzaei M, et al. (2017). Anticancer and apoptosis‑inducing effects of quercetin in vitro and in vivo.
15. Hunter P. (2012). The inflammation theory of disease. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment
16. .Jin F, et al. (2010). The variable plasma quercetin response to 12-week quercetin supplementation in humans.
17. (2016). Bioavailability of quercetin.
18. Knab A M, et al. (2011). Influence of quercetin supplementation on disease risk factors in community-dwelling adults.
19. Khansari N, et al. (2009). Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer.
20. Kozłowska A, et al. (2014). Flavonoids--food sources and health benefits.
21. Kressler J, et al. (2011). Quercetin and endurance exercise capacity: a systematic review and meta-analysis.
22. Lee M, et al. (2016). Quercetin, not caffeine, is a major neuroprotective component in coffee.
23. Leyva-López N, et al. (2016). Flavonoids as cytokine modulators: A possible therapy for inflammation-related diseases.
24. Lu Y, et al. (2018). Quercetin enrich diet during the early-middle not middle-late stage of alzheimer's disease ameliorates cognitive dysfunction.
25. Mitchell A E, et al. (2007). Ten-year comparison of the influence of organic and conventional crop management practices on the content of flavonoids in tomatoes.
26. Ostadmohammadi V, et al. (2019). Effects of quercetin supplementation on glycemic control among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials.
27. Pham-Huy L A, et al. (2008). Free radicals, antioxidants in disease and health.
28. Sabogal-Guáqueta A M, et al. (2015). The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice.
29. Serban M-C, et al. (2016). Effects of quercetin on blood pressure: A systematic review and meta-analysis of randomized controlled trials.
30. Shi G-J, et al. (2019). In vitro and in vivo evidence that quercetin protects against diabetes and its complications: A systematic review of the literature.
31. Xu M, et al. (2018). Senolytics improve physical function and increase lifespan in old age.
32. Yang F, et al. (2015). Quercetin in prostate cancer: Chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential (Review).
33. Zhou J, et al. (2017). Investigation of the anti-cancer effect of quercetin on HepG2 cells in vivo.
    

Links to Research: Glutathione

1. About peripheral artery disease (PAD). (2017).
2. Arosio E, et al. (2002). Effect of glutathioneinfusion on leg arterial circulation, cutaneous microcirculation, and pain-freewalking distance in patients with peripheral obstructive arterial disease: arandomized, double-blind, placebo-controlled http://dx.doi.org/10.4065/77.8.754
   
3. Balendiran GK, et al. (2004). The role ofglutathione in cancer. DOI: https://doi.org/10.1002/cbf.1149
   
4. Traverso N, et al. (2013). Role of glutathionein cancer progression and chemoresistance. https://www.omicsonline.org/references/role-of-glutathione-in-cancer-progression-and-chemoresistance-359310.html
   
5. Singh RJ. (2002).Glutathione: A marker and antioxidant for aging. DOI: http://dx.doi.org/10.1067/mlc.2002.129505
   
6. Sekhar RJ, et al. (2011). Glutathione synthesisis diminished in patients with uncontrolled diabetes and restored by dietarysupplementation with cysteine and glycine. DOI: https://doi.org/10.2337/dc10-1006
   
7. Rose S, et al. (2012). Evidence of oxidativedamage and inflammation associated with low glutathione redox status in theautism brain. DOI: https://doi.org/10.1038/tp.2012.61
   
8. Perricone C,et al. (2009). Glutathione: A key player in autoimmunity. DOI: https://doi.org/10.1016/j.autrev.2009.02.020
   
9. Pathak D.(2013). Correcting glutathione deficiency improves impaired mitochondrial fatburning, insulin resistance in aging. https://www.bcm.edu/news/geriatrics/glutathione-deficiency-fat-insulin-aging
   
10. Otto M, etal. (2017). The use of intravenous glutathione for symptom management ofParkinson’s disease: A case report. https://www.ncbi.nlm.nih.gov/pubmed/29101773
    
11. Kerksick C,et al. (2005). The antioxidant role of glutathione and N-acetyl-cysteinesupplements and exercise-induced oxidative stress. DOI: https://doi.org/10.1186/1550-2783-2-2-38
    
12. Hassan MQ.(2001). The glutathione defense system in the pathogenesis of rheumatoid arthritis https://www.ncbi.nlm.nih.gov/pubmed/11180282
    
13. Fairbanks KD.(2012). Alcoholic liver disease.http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/hepatology/alcoholic-liver-disease/
    
14. Droge W, etal. (2000). Glutathione and immune function.https://www.ncbi.nlm.nih.gov/pubmed/11115795
    
15. DesaulniersV. (2016). Glutathione and cancer.https://beatcancer.org/blog-posts/glutathione-and-cancer
    
16. Dentico P,et al. (1995). Glutathione in the treatment of chronic fatty liver diseases.https://www.ncbi.nlm.nih.gov/pubmed/7569285
    
17. Bayani U, etal. (2009). Oxidative stress and neurodegenerative diseases: A review ofupstream and downstream antioxidant therapeutic options. DOI: https://doi.org/10.2174/157015909787602823